10.1021/ol802608r.s001
Yuanhong Zhao
Yuanhong
Zhao
Yongyun Zhou
Yongyun
Zhou
Leilei Liang
Leilei
Liang
Xiaodong Yang
Xiaodong
Yang
Fengxiang Du
Fengxiang
Du
Liang Li
Liang
Li
Hongbin Zhang
Hongbin
Zhang
Palladium-Catalyzed Sequential Arylation and Allylic Alkylation of Highly Functionalized Ketones: A Concise Synthesis of Mesembrine
American Chemical Society
2009
Allylic Alkylation
building blocks
Concise Synthesis
functionalized cyclohexenones
mesembrine
Arylation
sequential
allylic alkylation
arylation
benzylic quaternary carbon
Mesembrine
Sequential
Functionalized Ketones
synthesis
procedure
2009-02-05 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Palladium_Catalyzed_Sequential_Arylation_and_Allylic_Alkylation_of_Highly_Functionalized_Ketones_A_Concise_Synthesis_of_Mesembrine/2880745
An unprecedented palladium-catalyzed sequential procedure toward arylation and allylic alkylation of highly functionalized cyclohexenones was developed. This new protocol leads to useful building blocks containing a benzylic quaternary carbon in only one step. A concise total synthesis of mesembrine based on this procedure was achieved in only five steps with 22% overall yield.