10.1021/ol802608r.s001 Yuanhong Zhao Yuanhong Zhao Yongyun Zhou Yongyun Zhou Leilei Liang Leilei Liang Xiaodong Yang Xiaodong Yang Fengxiang Du Fengxiang Du Liang Li Liang Li Hongbin Zhang Hongbin Zhang Palladium-Catalyzed Sequential Arylation and Allylic Alkylation of Highly Functionalized Ketones: A Concise Synthesis of Mesembrine American Chemical Society 2009 Allylic Alkylation building blocks Concise Synthesis functionalized cyclohexenones mesembrine Arylation sequential allylic alkylation arylation benzylic quaternary carbon Mesembrine Sequential Functionalized Ketones synthesis procedure 2009-02-05 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Palladium_Catalyzed_Sequential_Arylation_and_Allylic_Alkylation_of_Highly_Functionalized_Ketones_A_Concise_Synthesis_of_Mesembrine/2880745 An unprecedented palladium-catalyzed sequential procedure toward arylation and allylic alkylation of highly functionalized cyclohexenones was developed. This new protocol leads to useful building blocks containing a benzylic quaternary carbon in only one step. A concise total synthesis of mesembrine based on this procedure was achieved in only five steps with 22% overall yield.