Highly Enantioselective Hydrogenation of Enamides Catalyzed by Chiral Phosphoric Acids Guilong Li Jon C. Antilla 10.1021/ol802860u.s001 https://acs.figshare.com/articles/journal_contribution/Highly_Enantioselective_Hydrogenation_of_Enamides_Catalyzed_by_Chiral_Phosphoric_Acids/2873881 A highly enantioselective hydrogenation of enamides catalyzed by a dual chiral−achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product. 2009-03-05 00:00:00 Chiral Phosphoric Acids enantioselective hydrogenation chiral catalyst chiral phosphoric acid Enamides Catalyzed reduction product Enantioselective Hydrogenation acetic acid substoichiometric amount catalyst loadings