Highly Enantioselective Hydrogenation of Enamides Catalyzed by Chiral Phosphoric Acids
Guilong Li
Jon C. Antilla
10.1021/ol802860u.s001
https://acs.figshare.com/articles/journal_contribution/Highly_Enantioselective_Hydrogenation_of_Enamides_Catalyzed_by_Chiral_Phosphoric_Acids/2873881
A highly enantioselective hydrogenation of enamides catalyzed by a dual chiral−achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product.
2009-03-05 00:00:00
Chiral Phosphoric Acids
enantioselective hydrogenation
chiral catalyst
chiral phosphoric acid
Enamides Catalyzed
reduction product
Enantioselective Hydrogenation
acetic acid
substoichiometric amount
catalyst loadings