10.1021/ol802860u.s001 Guilong Li Guilong Li Jon C. Antilla Jon C. Antilla Highly Enantioselective Hydrogenation of Enamides Catalyzed by Chiral Phosphoric Acids American Chemical Society 2009 Chiral Phosphoric Acids enantioselective hydrogenation chiral catalyst chiral phosphoric acid Enamides Catalyzed reduction product Enantioselective Hydrogenation acetic acid substoichiometric amount catalyst loadings 2009-03-05 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Highly_Enantioselective_Hydrogenation_of_Enamides_Catalyzed_by_Chiral_Phosphoric_Acids/2873881 A highly enantioselective hydrogenation of enamides catalyzed by a dual chiral−achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product.