10.1021/ol802860u.s001
Guilong Li
Guilong
Li
Jon C. Antilla
Jon C.
Antilla
Highly Enantioselective Hydrogenation of Enamides Catalyzed by Chiral Phosphoric Acids
American Chemical Society
2009
Chiral Phosphoric Acids
enantioselective hydrogenation
chiral catalyst
chiral phosphoric acid
Enamides Catalyzed
reduction product
Enantioselective Hydrogenation
acetic acid
substoichiometric amount
catalyst loadings
2009-03-05 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Highly_Enantioselective_Hydrogenation_of_Enamides_Catalyzed_by_Chiral_Phosphoric_Acids/2873881
A highly enantioselective hydrogenation of enamides catalyzed by a dual chiral−achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product.