Ríos-Lombardía, Nicolás Busto, Eduardo García-Urdiales, Eduardo Gotor-Fernández, Vicente Gotor, Vicente Enzymatic Desymmetrization of Prochiral 2-Substituted-1,3-Diamines: Preparation of Valuable Nitrogenated Compounds A wide range of prochiral 1,3-diamines were first efficiently synthesized and subsequently desymmetrized by using lipase from Pseudomonas cepacia as catalyst and diallyl carbonate as alkoxycarbonylating agent. In all cases, the amino carbamates of <i>R</i>-configuration were recovered. Final selective cleavage of the <i>N</i>-allyloxycarbonyl moiety was carried out under mild reaction conditions, which demonstrates the high versatility and potential of this chemoenzymatic route as a source of intermediates in the synthesis of related optically active nitrogenated derivatives. reaction conditions;prochiral;diamine;Final;carbamate;alkoxycarbonylating agent;nitrogenated derivatives;source;moiety;Substituted;diallyl carbonate;synthesis;Preparation;Pseudomonas cepacia;catalyst;intermediate;versatility;lipase;Valuable Nitrogenated Compounds;Enzymatic Desymmetrization;Prochiral;desymmetrized;cleavage;chemoenzymatic route 2009-03-20
    https://acs.figshare.com/articles/journal_contribution/Enzymatic_Desymmetrization_of_Prochiral_2_Substituted_1_3_Diamines_Preparation_of_Valuable_Nitrogenated_Compounds/2869927
10.1021/jo8025912.s001