10.1021/np900029z.s001
Li-She Gan
Li-She
Gan
Gang Ren
Gang
Ren
Jian-Xia Mo
Jian-Xia
Mo
Xiang-Yi Zhang
Xiang-Yi
Zhang
Wei Yao
Wei
Yao
Chang-Xin Zhou
Chang-Xin
Zhou
Cycloartane Triterpenoids from <i>Kleinhovia hospita</i>
American Chemical Society
2009
gardenolic acid B
Hep
Cycloartane Triterpenoids
diacetal
compound 4
IR
Kleinhovia hospita
cycloartane triterpenoids
configuration
cytotoxicity
spectroscopic methods
Kleinhovia hospitaFour
hepatoprotective effects
2 D NMR
ketone moieties
2009-06-26 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Cycloartane_Triterpenoids_from_i_Kleinhovia_hospita_i_/2847457
Four new cycloartane triterpenoids, together with the known gardenolic acid B, were isolated from <i>Kleinhovia hospita</i>. The triterpenoids (<b>1</b>−<b>3</b>) contain a unique 21,23-diacetal side-chain, while compound <b>4</b> contains two α,β-unsaturated ketone moieties. Their structures and relative configurations were determined by spectroscopic methods, including 2D NMR and IR. These compounds showed promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.