10.1021/pr800937k.s003
Verena S. Meyer
Verena S.
Meyer
Oliver Drews
Oliver
Drews
Marc Günder
Marc
Günder
Jörg Hennenlotter
Jörg
Hennenlotter
Hans-Georg Rammensee
Hans-Georg
Rammensee
Stefan Stevanovic
Stefan
Stevanovic
Identification of Natural MHC Class II Presented Phosphopeptides and Tumor-Derived MHC Class I Phospholigands
American Chemical Society
2009
phosphorylated MHC class
cell carcinoma
phosphorylated MHC class II ligands
CXCR
tumor tissue
transmembrane receptors
novel phosphorylation sites
PhospholigandsMHC molecules
T lymphocytes
Natural MHC Class II Presented Phosphopeptides
2009-07-06 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Identification_of_Natural_MHC_Class_II_Presented_Phosphopeptides_and_Tumor_Derived_MHC_Class_I_Phospholigands/2845684
MHC molecules present protein-derived peptides to T lymphocytes. By developing TiO<sub>2</sub>-based microcentrifugation columns, we identified the first phosphorylated MHC class I ligands from tumor tissue (renal cell carcinoma) and, by comparison to healthy renal tissue, found one Brf1-derived ligand as potentially tumor-associated. We further discovered the first natural phosphorylated MHC class II ligands. They revealed several novel phosphorylation sites of significant transmembrane receptors, such as Frizzled 6, CXCR4 and CD20.