β,β-Disubstituted <i>C</i>- and <i>N</i>-Vinylindoles from One-Step Condensations of Aldehydes and Indole Derivatives Gil Fridkin Nicolas Boutard William D. Lubell 10.1021/jo900526p.s001 https://acs.figshare.com/articles/journal_contribution/_Disubstituted_i_C_i_and_i_N_i_Vinylindoles_from_One_Step_Condensations_of_Aldehydes_and_Indole_Derivatives/2837047 Direct preparation of β,β-disubstituted <i>C</i>- and <i>N</i>-vinylindoles from condensation of aldehydes on indole derivatives is presented. Heating 1-methyl- and 1-benzylindole <b>3a</b>,<b>b</b> with alkyl and aryl α-branched aldehydes and TFA in acetonitrile using microwave irradiation furnished 3-vinylindoles <b>1a</b>−<b>e</b> in 18−76% yields. Under similar conditions, 3-substituted indoles <b>4a</b>−<b>c</b> provided <i>N</i>-vinylindoles <b>2a</b>−<b>h</b> in 16−98% yields. 2009-08-07 00:00:00 indoles 4 methyl yield Aldehyde aldehyde Indole DerivativesDirect preparation benzylindole vinylindole acetonitrile Condensation Heating Disubstituted indole derivatives microwave irradiation condensation alkyl TFA disubstituted aryl