Zn(II)-Catalyzed Synthesis of Piperidines from Propargyl Amines and Cyclopropanes
Terry P. Lebold
Andrew B. Leduc
Michael A. Kerr
10.1021/ol901435k.s001
https://acs.figshare.com/articles/journal_contribution/Zn_II_Catalyzed_Synthesis_of_Piperidines_from_Propargyl_Amines_and_Cyclopropanes/2834305
The reaction of benzyl-protected propargyl amines and 1,1-cyclopropane diesters in the presence of catalytic Zn(NTf<sub>2</sub>)<sub>2</sub> allows access to highly functionalized piperidines in excellent yields. The process proceeds via a tandem cyclopropane ring-opening/Conia−ene cyclization.
2009-08-20 00:00:00
Piperidine
presence
cyclization
access
Propargyl Amines
Cyclopropane
propargyl
Synthesi
amines
diester
functionalized piperidines
cyclopropane
Zn
yield
tandem
process proceeds