10.1021/ol9014893.s002 Takanori Shibata Takanori Shibata Toshifumi Uchiyama Toshifumi Uchiyama Kohei Endo Kohei Endo Enantioselective Synthesis of Chiral Tripodal Cage Compounds by [2 + 2 + 2] Cycloaddition of Branched Triynes American Chemical Society 2009 tripodal aminophenol macrocyclic compound Rh Branched Triynes Cyclotrimerization cycloadduct cationic ee method cyclophane diyne intramolecular reaction nitrogen atom catalyst cage Chiral Tripodal Cage Compounds triarmed pyridinophane triyne Enantioselective Synthesis synthesis Cycloaddition 2009-09-03 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Enantioselective_Synthesis_of_Chiral_Tripodal_Cage_Compounds_by_2_2_2_Cycloaddition_of_Branched_Triynes/2830792 Cyclotrimerization of triynes branched by a nitrogen atom of 2-aminophenol yielded planar-chiral tripodal cage compounds. When a cationic Rh−Me-DUPHOS catalyst was used, the cycloadducts were obtained in high yield and excellent ee, and a macrocyclic compound with a [15]cyclophane system was also obtained. This method can be further applied to the synthesis of a triarmed pyridinophane by the intramolecular reaction of a diyne−nitrile.