10.1021/ol9014893.s002
Takanori Shibata
Takanori
Shibata
Toshifumi Uchiyama
Toshifumi
Uchiyama
Kohei Endo
Kohei
Endo
Enantioselective Synthesis of Chiral Tripodal Cage Compounds by [2 + 2 + 2] Cycloaddition of Branched Triynes
American Chemical Society
2009
tripodal
aminophenol
macrocyclic compound
Rh
Branched Triynes Cyclotrimerization
cycloadduct
cationic
ee
method
cyclophane
diyne
intramolecular reaction
nitrogen atom
catalyst
cage
Chiral Tripodal Cage Compounds
triarmed pyridinophane
triyne
Enantioselective Synthesis
synthesis
Cycloaddition
2009-09-03 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Enantioselective_Synthesis_of_Chiral_Tripodal_Cage_Compounds_by_2_2_2_Cycloaddition_of_Branched_Triynes/2830792
Cyclotrimerization of triynes branched by a nitrogen atom of 2-aminophenol yielded planar-chiral tripodal cage compounds. When a cationic Rh−Me-DUPHOS catalyst was used, the cycloadducts were obtained in high yield and excellent ee, and a macrocyclic compound with a [15]cyclophane system was also obtained. This method can be further applied to the synthesis of a triarmed pyridinophane by the intramolecular reaction of a diyne−nitrile.