10.1021/acsnano.5b08025.s002
Ye Liu
Ye
Liu
Yekkuni
L Balachandran
Yekkuni
L
Balachandran
Dan Li
Dan
Li
Yiming Shao
Yiming
Shao
Xingyu Jiang
Xingyu
Jiang
Polyvinylpyrrolidone–Poly(ethylene
glycol)
Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV
Vaccine
American Chemical Society
2016
Such silver nanorods
Modified Silver Nanorods
PEG
PVP
adjuvant
immunity
material
HIV vaccine
glycol
2016-02-04 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Polyvinylpyrrolidone_Poly_ethylene_glycol_Modified_Silver_Nanorods_Can_Be_a_Safe_Noncarrier_Adjuvant_for_HIV_Vaccine/2827780
One
of the biggest obstacles for the development of HIV vaccines
is how to sufficiently trigger crucial anti-HIV immunities via a safe
manner. We herein integrated surface modification-dependent immunostimulation
against HIV vaccine and shape-dependent biosafety and designed a safe
noncarrier adjuvant based on silver nanorods coated by both polyvinylpyrrolidone
(PVP) and polyethylene glycol (PEG). Such silver nanorods can significantly
elevate crucial immunities of HIV vaccine and overcome the toxicity,
which is a big problem for other existing adjuvants. This study thus
provided a principle for designing a safe and high-efficacy material
for an adjuvant and allow researchers to really have a safe and effective
prophylaxis against HIV. We expect this material approach to be applicable
to other types of vaccines, whether they are preventative or therapeutic.