Synthetic Study on Tetrapetalones: Stereoselective Cyclization of <i>N</i>-Acyliminium Ion To Construct Substituted 1-Benzazepines
Cheng Li
Xinyu Li
Ran Hong
10.1021/ol901349b.s002
https://acs.figshare.com/articles/dataset/Synthetic_Study_on_Tetrapetalones_Stereoselective_Cyclization_of_i_N_i_Acyliminium_Ion_To_Construct_Substituted_1_Benzazepines/2827426
The synthesis of the tetracyclic core of complex antibiotic tetrapetalones has been achieved in three steps starting from the simple intermediate γ-hydroxy amide, which can be accessed through a high-yielding six-step sequence. The successful synthesis relies on a novel strategy based on the <i>N</i>-acyliminium ion cyclization.
2009-09-17 00:00:00
tetracyclic core
sequence
novel strategy
Synthetic Study
antibiotic tetrapetalones
cyclization
Ion
Substituted
Stereoselective Cyclization
synthesis
Benzazepine
Tetrapetalone
amide
hydroxy