%0 Journal Article %A Guinchard, Xavier %A Roulland, Emmanuel %D 2009 %T Total Synthesis of the Antiproliferative Macrolide (+)-Neopeltolide %U https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_the_Antiproliferative_Macrolide_Neopeltolide/2821324 %R 10.1021/ol902047z.s001 %2 https://acs.figshare.com/ndownloader/files/4518979 %K diastereoselective %K propargylation %K stereoselective %K 16 steps %K antiproliferative %K Pd %K neopeltolide %K desulfurative %K thank %K reliance %K approach %K synthesis %K Macrolide %K stereogenic centers %K macrolide %K Total Synthesis %K alkyne %K Antiproliferative %K Neopeltolide %X A concise total synthesis of the very promising antiproliferative macrolide (+)-neopeltolide (1) has been performed in 16 steps. The main steps of this approach are a RuII-catalyzed alkyne−enal coupling, a Pd0-catalyzed desulfurative cross-coupling, and a stereoselective InIII-catalyzed propargylation. Four stereogenic centers out of six have been set thanks to substrate-controlled diastereoselective reactions with minimal reliance on protecting groups. %I ACS Publications