%0 Journal Article
%A Guinchard, Xavier
%A Roulland, Emmanuel
%D 2009
%T Total Synthesis of the Antiproliferative Macrolide (+)-Neopeltolide
%U https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_the_Antiproliferative_Macrolide_Neopeltolide/2821324
%R 10.1021/ol902047z.s001
%2 https://acs.figshare.com/ndownloader/files/4518979
%K diastereoselective
%K propargylation
%K stereoselective
%K 16 steps
%K antiproliferative
%K Pd
%K neopeltolide
%K desulfurative
%K thank
%K reliance
%K approach
%K synthesis
%K Macrolide
%K stereogenic centers
%K macrolide
%K Total Synthesis
%K alkyne
%K Antiproliferative
%K Neopeltolide
%X A concise total synthesis of the very promising antiproliferative macrolide (+)-neopeltolide (1) has been performed in 16 steps. The main steps of this approach are a RuII-catalyzed alkyne−enal coupling, a Pd0-catalyzed desulfurative cross-coupling, and a stereoselective InIII-catalyzed propargylation. Four stereogenic centers out of six have been set thanks to substrate-controlled diastereoselective reactions with minimal reliance on protecting groups.
%I ACS Publications