Total Synthesis of the Antiproliferative Macrolide (+)-Neopeltolide Xavier Guinchard Emmanuel Roulland 10.1021/ol902047z.s001 https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_the_Antiproliferative_Macrolide_Neopeltolide/2821324 A concise total synthesis of the very promising antiproliferative macrolide (+)-neopeltolide (<b>1</b>) has been performed in 16 steps. The main steps of this approach are a Ru<sup>II</sup>-catalyzed alkyne−enal coupling, a Pd<sup>0</sup>-catalyzed desulfurative cross-coupling, and a stereoselective In<sup>III</sup>-catalyzed propargylation. Four stereogenic centers out of six have been set thanks to substrate-controlled diastereoselective reactions with minimal reliance on protecting groups. 2009-10-15 00:00:00 diastereoselective propargylation stereoselective 16 steps antiproliferative Pd neopeltolide desulfurative thank reliance approach synthesis Macrolide stereogenic centers macrolide Total Synthesis alkyne Antiproliferative Neopeltolide