Total Synthesis of the Antiproliferative Macrolide (+)-Neopeltolide
Xavier Guinchard
Emmanuel Roulland
10.1021/ol902047z.s001
https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_the_Antiproliferative_Macrolide_Neopeltolide/2821324
A concise total synthesis of the very promising antiproliferative macrolide (+)-neopeltolide (<b>1</b>) has been performed in 16 steps. The main steps of this approach are a Ru<sup>II</sup>-catalyzed alkyne−enal coupling, a Pd<sup>0</sup>-catalyzed desulfurative cross-coupling, and a stereoselective In<sup>III</sup>-catalyzed propargylation. Four stereogenic centers out of six have been set thanks to substrate-controlled diastereoselective reactions with minimal reliance on protecting groups.
2009-10-15 00:00:00
diastereoselective
propargylation
stereoselective
16 steps
antiproliferative
Pd
neopeltolide
desulfurative
thank
reliance
approach
synthesis
Macrolide
stereogenic centers
macrolide
Total Synthesis
alkyne
Antiproliferative
Neopeltolide