%0 Journal Article
%A Jia, Xiaofei
%A Yang, Dongpeng
%A Wang, Wenhui
%A Luo, Fang
%A Cheng, Jiang
%D 2009
%T Chelation-Assisted Palladium-Catalyzed Cascade Bromination/Cyanation Reaction of 2-Arylpyridine and 1-Arylpyrazole C−H Bonds
%U https://acs.figshare.com/articles/journal_contribution/Chelation_Assisted_Palladium_Catalyzed_Cascade_Bromination_Cyanation_Reaction_of_2_Arylpyridine_and_1_Arylpyrazole_C_H_Bonds/2805583
%R 10.1021/jo902185c.s001
%2 https://acs.figshare.com/ndownloader/files/4500088
%K arylpyrazole
%K fluoro
%K arylpyridine
%K carbomethoxy groups
%K nitrile
%K BondsA
%K Bromination
%K cyanide source
%K cyano
%K bromination
%K Cascade
%K chloro
%K trifluoromethyl
%K Arylpyrazole
%K yield
%K cascade
%K procedure
%K Arylpyridine
%K bond
%X A chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C−H bonds has been developed. Notably, the reaction employs K3[Fe(CN)6] as a safe and nontoxic cyanide source, providing aromatic nitriles in moderate to good yields in one-pot. The procedure tolerates methoxy, chloro, fluoro, cyano, trifluoromethyl, and carbomethoxy groups.
%I ACS Publications