10.1021/jo902160y.s001
Keiichi Hirano
Keiichi
Hirano
Akkattu T. Biju
Akkattu T.
Biju
Frank Glorius
Frank
Glorius
Copper-Catalyzed Synthesis of 2-Unsubstituted, <i>N</i>-Substituted Benzimidazoles
American Chemical Society
2009
intramolecular
yield
arylation
benzimidazole
utility
sterically
method
Synthesi
Me
BenzimidazolesAn
substituent
Unsubstituted
diisopropylphenyl
formamidine
unsubstituted
2009-12-18 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Copper_Catalyzed_Synthesis_of_2_Unsubstituted_i_N_i_Substituted_Benzimidazoles/2805580
An efficient copper-catalyzed intramolecular arylation of formamidines forming 2-unsubstituted benzimidazoles in excellent yields is reported. Sixteen examples bearing sterically demanding substituents on nitrogen like Mes, 2,6-diisopropylphenyl, or 2-<i>tert</i>-butylphenyl and tolerating various functional groups demonstrate the utility of this method.