%0 Journal Article
%A Lu, Hongjian
%A Subbarayan, Velusamy
%A Tao, Jingran
%A Zhang, X. Peter
%D 2010
%T Cobalt(II)-Catalyzed Intermolecular Benzylic C−H Amination with 2,2,2-Trichloroethoxycarbonyl Azide (TrocN3)
%U https://acs.figshare.com/articles/journal_contribution/Cobalt_II_Catalyzed_Intermolecular_Benzylic_C_H_Amination_with_2_2_2_Trichloroethoxycarbonyl_Azide_TrocN_sub_3_sub_/2797660
%R 10.1021/om900916g.s001
%2 https://acs.figshare.com/ndownloader/files/4492072
%K Azide
%K nitrene source
%K cobalt
%K metalloporphyrin
%K additive
%K azide
%K Trichloroethoxycarbonyl
%K Amination
%K nitrogen gas
%K byproduct
%K Benzylic
%K amines
%K reagent
%K nitrene insertion
%K catalyst
%K TrocN
%K benzylic
%K Co
%K yield
%K Cobalt
%K amination
%K Intermolecular
%K bond
%X 2,2,2-Trichloroethoxycarbonyl azide (TrocN3) is an effective nitrene source for cobalt(II)-catalyzed intermolecular nitrene insertion of C−H bonds. Among different metalloporphyrins studied, Co(II)(TPP) was shown to be a competent catalyst for the selective amination of various benzylic C−H bonds under mild conditions without the need of other reagents or additives, forming the desired Troc-protected amines in moderate to high yields with nitrogen gas as the only byproduct.
%I ACS Publications