10.1021/np100044t.s002 Guo-An Zou Guo-An Zou Gang Ding Gang Ding Zhi-Heng Su Zhi-Heng Su Jun-Shan Yang Jun-Shan Yang Hone-Wu Zhang Hone-Wu Zhang Chao-Zhong Peng Chao-Zhong Peng Haiji Akber Aisa Haiji Akber Aisa Zhong-Mei Zou Zhong-Mei Zou Lactonecembranoids from <i>Croton laevigatus</i> American Chemical Society 2010 38.4 μ M compound laevigatlactone Croton laevigatusSix acid crystallography basis Lactonecembranoid cembranoid Croton laevigatus spectroscopic analysis cytotoxicity IC 50 value Compound 2 neocrotocembraneic HeLa cells 2010-04-23 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Lactonecembranoids_from_i_Croton_laevigatus_i_/2774791 Six new cembranoids, laevigatlactones A−F (<b>1</b>−<b>6</b>), and the known compound neocrotocembraneic acid (<b>7</b>) were isolated from leaves of <i>Croton laevigatus</i>. Their structures were elucidated on the basis of spectroscopic analysis, and that of <b>1</b> was confirmed by X-ray crystallography. Compound <b>2</b> exhibited modest cytotoxicity against HeLa cells, with an IC<sub>50</sub> value of 38.4 μM.