%0 Online Multimedia %A Febvay, SeĢbastien %A Marini, Davide M. %A Belcher, Angela M. %A Clapham, David E. %D 2010 %T Targeted Cytosolic Delivery of Cell-Impermeable Compounds by Nanoparticle-Mediated, Light-Triggered Endosome Disruption %U https://acs.figshare.com/articles/media/Targeted_Cytosolic_Delivery_of_Cell_Impermeable_Compounds_by_Nanoparticle_Mediated_Light_Triggered_Endosome_Disruption/2762740 %R 10.1021/nl101157z.s003 %2 https://acs.figshare.com/ndownloader/files/4456663 %K cancer cells %K delivery method %K intracellular vesicles %K spatiotemporal control %K NP %K cargo release %K light activation %K biofunctionalized mesoporous silica nanoparticles %K Targeted Cytosolic Delivery %X Nanoparticle (NP)-mediated drug delivery typically relies on cargo release to occur passively or in response to environmental stimuli. Here we present a delivery method based on light-activated disruption of intracellular vesicles after internalization of biofunctionalized mesoporous silica nanoparticles loaded with cargo. This method combines the power of targeted delivery with the spatiotemporal control of light activation. As an example, we delivered a cell-impermeable fluorescent compound exclusively to the cytosol of multidrug resistant cancer cells in a mixed population. %I ACS Publications