10.1021/nl101355x.s001
Mohammad Reza Badrossamay
Mohammad Reza
Badrossamay
Holly Alice McIlwee
Holly Alice
McIlwee
Josue A. Goss
Josue A.
Goss
Kevin Kit Parker
Kevin Kit
Parker
Nanofiber Assembly by Rotary Jet-Spinning
American Chemical Society
2010
technique
nanofiber structures
polymer solution jets
building anisotropic arrays
fabrication
polymer solution properties
tissue
production rate limit electrospinning
2010-06-09 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Nanofiber_Assembly_by_Rotary_Jet_Spinning/2762737
High-voltage electrical fields and low production rate limit electrospinning, the electrical charging of polymer liquids, as a means of nanofiber fabrication. Here, we show a facile method of fabrication of aligned three-dimensional nanofiber structures by utilizing high-speed, rotating polymer solution jets to extrude fibers. Termed rotary jet-spinning, fiber morphology, diameter, and web porosity can be controlled by varying nozzle geometry, rotation speed, and polymer solution properties. We demonstrate the utility of this technique for tissue engineering by building anisotropic arrays of biodegradable polymer fibers and seeding the constructs with neonatal rat ventricular cardiomyocytes. The myocytes used the aligned fibers to orient their contractile cytoskeleton and to self-organize into a beating, multicellular tissue that mimics the laminar, anisotropic architecture of the heart muscle. This technique may prove advantageous for building uniaxially aligned nanofiber structures for polymers which are not amenable to fabrication by electrospinning.