Enantioselective Synthesis of 1-Aryltetrahydroisoquinolines WangSa OnaranM. Burak SetoChristopher T. 2010 1-Aryltetrahydroisoquinolines (1-arylTHIQs) are important structural motifs in many alkaloids and biologically active compounds. Ligand <b>2a</b> promotes the enantioselective addition of arylzinc reagents to 3,4-dihydroisoquinoline <i>N</i>-oxide to yield (<i>S</i>)-1-arylTHIQs in 97−99% ee. Pinacol arylboronic esters are the optimal precursors for the arylzinc reagents. This method is applied to the enantioselective synthesis of Solifenacin.