10.1021/om100331z.s002
Zhen Liu
Zhen
Liu
Min Shi
Min
Shi
Catalytic Enantioselective Addition of Cyclic β-Keto Esters with Activated Olefins and N-Boc Imines Using Chiral <i>C</i><sub>2</sub>-Symmetric Cationic Pd<sup>2+</sup> N-Heterocyclic Carbene (NHC) Diaqua Complexes
American Chemical Society
2010
Pd
Activated Olefins
NHC
Catalytic Enantioselective Addition
diaqua
Diaqua ComplexesThe
catalyst
2010-06-28 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Catalytic_Enantioselective_Addition_of_Cyclic_Keto_Esters_with_Activated_Olefins_and_N_Boc_Imines_Using_Chiral_i_C_i_sub_2_sub_Symmetric_Cationic_Pd_sup_2_sup_N_Heterocyclic_Carbene_NHC_Diaqua_Complexes/2757937
The asymmetric addition of cyclic β-keto esters to activated olefins and N-Boc imines was realized by using chiral cationic <i>C</i><sub>2</sub>-symmetric N-heterocyclic carbene (NHC) Pd<sup>2+</sup> diaqua complexes <b>1a</b>,<b>b</b> as the catalysts, producing the corresponding adducts in moderate to high yields (up to 95%) and with good to high enantioselectivities (up to 96% ee). Nevertheless, the most significant observation is that when the (<i>R</i>)-NHC Pd<sup>2+</sup> diaqua complex was used in these reactions, different absolute configurations were observed in comparison to those obtained with catalysts obtained from (<i>R</i>)-phosphane ligands.