10.1021/ol1011955.s004
Hua Yang
Hua
Yang
Rich G. Carter
Rich G.
Carter
Synthesis of All-Carbon, Quaternary Center-Containing Cyclohexenones through an Organocatalyzed, Multicomponent Coupling
American Chemical Society
2010
enamine
diastereoselectivity
functionalized cyclohexenones
accessing
Cyclohexenone
quaternary center
enantio
enantioselectivity
contrast
Synthesi
Organocatalyzed multicomponent
Quaternary
sieve
proline aryl sulfonamide
Multicomponent
2010-07-02 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Synthesis_of_All_Carbon_Quaternary_Center_Containing_Cyclohexenones_through_an_Organocatalyzed_Multicomponent_Coupling/2756356
Organocatalyzed multicomponent coupling using a new ester-containing, proline aryl sulfonamide has been developed for accessing densely functionalized cyclohexenones, each containing a quaternary center in high enantio- and diastereoselectivity. In contrast to most enamine/iminium-catalyzed reactions, the use of molecular sieves was critical to optimum enantioselectivity.