Enantio- and Diastereoselective Synthesis of Piperidines by Coupling of Four Components in a “One-Pot” Sequence Involving Diphenylprolinol Silyl Ether Mediated Michael Reaction Tatsuya Urushima Daisuke Sakamoto Hayato Ishikawa Yujiro Hayashi 10.1021/ol1018932.s001 https://acs.figshare.com/articles/journal_contribution/Enantio_and_Diastereoselective_Synthesis_of_Piperidines_by_Coupling_of_Four_Components_in_a_One_Pot_Sequence_Involving_Diphenylprolinol_Silyl_Ether_Mediated_Michael_Reaction/2721796 An efficient, asymmetric, four-component, one-pot synthesis of highly substituted piperidines with excellent diastereo- and enantioselectivity was established through the diphenylprolinol silyl ether mediated Michael reaction of aldehyde and nitroalkene, followed by the domino aza-Henry reaction/hemiaminalization reaction and a Lewis acid mediated allylation or cyanation reaction. All carbons of the piperidine ring are substituted with different groups, and its five contiguous stereocenters are completely controlled in both relative and absolute senses. 2010-10-15 00:00:00 Lewis acid Diphenylprolinol Silyl Ether Mediated Michael Reaction Diastereoselective Synthesis piperidine ring diphenylprolinol silyl ether cyanation reaction Michael reaction