10.1021/ol1018932.s001 Tatsuya Urushima Tatsuya Urushima Daisuke Sakamoto Daisuke Sakamoto Hayato Ishikawa Hayato Ishikawa Yujiro Hayashi Yujiro Hayashi Enantio- and Diastereoselective Synthesis of Piperidines by Coupling of Four Components in a “One-Pot” Sequence Involving Diphenylprolinol Silyl Ether Mediated Michael Reaction American Chemical Society 2010 Lewis acid Diphenylprolinol Silyl Ether Mediated Michael Reaction Diastereoselective Synthesis piperidine ring diphenylprolinol silyl ether cyanation reaction Michael reaction 2010-10-15 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Enantio_and_Diastereoselective_Synthesis_of_Piperidines_by_Coupling_of_Four_Components_in_a_One_Pot_Sequence_Involving_Diphenylprolinol_Silyl_Ether_Mediated_Michael_Reaction/2721796 An efficient, asymmetric, four-component, one-pot synthesis of highly substituted piperidines with excellent diastereo- and enantioselectivity was established through the diphenylprolinol silyl ether mediated Michael reaction of aldehyde and nitroalkene, followed by the domino aza-Henry reaction/hemiaminalization reaction and a Lewis acid mediated allylation or cyanation reaction. All carbons of the piperidine ring are substituted with different groups, and its five contiguous stereocenters are completely controlled in both relative and absolute senses.