10.1021/ol1021965.s001 Jim Li Jim Li Judy M. Suh Judy M. Suh Elbert Chin Elbert Chin Expedient Enantioselective Synthesis of the Δ<sup>4</sup>-Oxocene Cores of (+)-Laurencin and (+)-Prelaureatin American Chemical Society 2010 sequence stereoselective vinylsilane intramolecular insertion Laurencin Core laurencin enantioselective synthesis Prelaureatin core stereocontrolled cyclization Expedient Enantioselective Synthesis Oxocene tetrahydrofuran precursors silyl regio prelaureatin fragmentation oxocene cascade 2010-11-05 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Expedient_Enantioselective_Synthesis_of_the_sup_4_sup_Oxocene_Cores_of_Laurencin_and_Prelaureatin/2716372 An expedient enantioselective synthesis of the Δ<sup>4</sup>-oxocene cores present in (+)-laurencin and (+)-prelaureatin was accomplished in eight steps via a novel one-pot regio- and stereoselective ring cyclization−fragmentation−expansion cascade from the tetrahydrofuran precursors which were prepared by stereocontrolled cyclization from vinylsilanes. This process is highlighted by an intramolecular oxo-carbenoid insertion and a β-silyl fragmentation sequence.