Room-Temperature Metal-Free Electrophilic <i>5-endo</i>-Selective Iodocarbocyclization of 1,5-Enynes PradalAlexandre NasrAlexandre ToullecPatrick Y. MicheletVeronique 2010 A highly efficient NIS-promoted iodocarbocyclization reaction of various functionalized 1,5-enynes is described via a 5-<i>endo</i> diastereoselective process. The cyclizations are conducted in the presence of 1.2 equiv of <i>N</i>-iodosuccinimide in dichloromethane at room temperature. The reaction conditions are compatible with several functional groups and lead to original iodo-functionalized carbocycles in good to excellent yields.