Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation Chunliang Lu Qing Xiao Paul E. Floreancig 10.1021/ol102246d.s001 https://acs.figshare.com/articles/journal_contribution/Stereoselective_Synthesis_of_Spirooxindole_Amides_through_Nitrile_Hydrozirconation/2711680 Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit. The products are well-suited for diversification to prepare libraries. 2010-11-19 00:00:00 stereochemical outcome diversification Stereoselective Synthesis Nitrile Hydrozirconation Spirooxindole amides quaternary center acylation acylimine intramolecular addition functionalized indoles substituent nitrile Spirooxindole Amides steric bulk hydrozirconation indole unit