Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation
Chunliang Lu
Qing Xiao
Paul E. Floreancig
10.1021/ol102246d.s001
https://acs.figshare.com/articles/journal_contribution/Stereoselective_Synthesis_of_Spirooxindole_Amides_through_Nitrile_Hydrozirconation/2711680
Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit. The products are well-suited for diversification to prepare libraries.
2010-11-19 00:00:00
stereochemical outcome
diversification
Stereoselective Synthesis
Nitrile Hydrozirconation Spirooxindole amides
quaternary center
acylation
acylimine
intramolecular addition
functionalized indoles
substituent
nitrile
Spirooxindole Amides
steric bulk
hydrozirconation
indole unit