%0 Journal Article %A Shi, Zugui %A Tan, Bin %A Wen Yi Leong, Wendy %A Zeng, Xiaofei %A Lu, Min %A Zhong, Guofu %D 2010 %T Catalytic Asymmetric Formal [4 + 1] Annulation Leading to Optically Active cis-Isoxazoline N-Oxides %U https://acs.figshare.com/articles/journal_contribution/Catalytic_Asymmetric_Formal_4_1_Annulation_Leading_to_Optically_Active_i_cis_i_Isoxazoline_i_N_i_Oxides/2707711 %R 10.1021/ol102181r.s001 %2 https://acs.figshare.com/ndownloader/files/4383658 %K novel use %K Catalytic %K functionalized %K Zhong %K Tetrahedron %K Annulation %K Optically %K Juaristi %K Zhang %K Asymmetric %K annulation %K strategy %K nitroacrylate %K Chem %K synthesis %K Zhu %K iodoaldehyde %K Chua %K Zeng %K organocatalyst %K Tan %K Formal %X The catalytic asymmetric synthesis of densely functionalized cis-isoxazoline N-oxides was realized with novel use of an organocatalyst, (S)-2-(azidodiphenylmethyl)pyrrolidine (4e) (Tan, B.; Zhu, D.; Zhang, L.; Chua, P. J.; Zeng, X.; Zhong, G. Chem.−Eur. J. 2010, 16, 3842; Olivares-Romero, J. L.; Juaristi, E. Tetrahedron 2008, 64, 9992), via an elegant formal [4 + 1] annulation strategy using readily available 2-nitroacrylates and α-iodoaldehydes. %I ACS Publications