Stereoselective Synthesis and Structural Correction of the Naturally Occurring Lactone Stagonolide G
César A. Angulo-Pachón
Santiago Díaz-Oltra
Juan Murga
Miguel Carda
J. Alberto Marco
10.1021/ol102599e.s002
https://acs.figshare.com/articles/journal_contribution/Stereoselective_Synthesis_and_Structural_Correction_of_the_Naturally_Occurring_Lactone_Stagonolide_G/2704228
A convergent synthesis of the structure proposed for the naturally occurring lactone stagonolide G is described. All three stereocenters were created with the aid of asymmetric Brown allylations. The lactone ring was built by means of a ring-closing metathesis (RCM). The synthetic and the natural compound differed in their spectral properties. A new structure is now proposed for stagonolide G and demonstrated by means of a chemical transformation.
2010-12-17 00:00:00
stereocenter
metathesi
RCM
Stereoselective Synthesis
Brown allylations
lactone stagonolide G
Structural Correction
chemical transformation
lactone ring
compound
Occurring Lactone Stagonolide G
stagonolide G
aid
convergent synthesis