10.1021/nn100870z.s001
Raja Shekar Rachakatla
Raja Shekar
Rachakatla
Sivasai Balivada
Sivasai
Balivada
Gwi-Moon Seo
Gwi-Moon
Seo
Carl B. Myers
Carl B.
Myers
Hongwang Wang
Hongwang
Wang
Thilani N. Samarakoon
Thilani N.
Samarakoon
Raj Dani
Raj
Dani
Marla Pyle
Marla
Pyle
Franklin O. Kroh
Franklin O.
Kroh
Brandon Walker
Brandon
Walker
Xiaoxuan Leaym
Xiaoxuan
Leaym
Olga B. Koper
Olga B.
Koper
Viktor Chikan
Viktor
Chikan
Stefan H. Bossmann
Stefan H.
Bossmann
Masaaki Tamura
Masaaki
Tamura
Deryl L. Troyer
Deryl L.
Troyer
Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells
American Chemical Society
2010
cell delivery vehicles
AMF
MNP
melanoma
progenitor cells
NPC
tumor
Neural Progenitor CellsLocalized
2010-12-28 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Attenuation_of_Mouse_Melanoma_by_A_C_Magnetic_Field_after_Delivery_of_Bi_Magnetic_Nanoparticles_by_Neural_Progenitor_Cells/2702131
Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane−porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe<sub>3</sub>O<sub>4</sub> MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (<i>p</i> < 0.05) a short time (24 h) after the last of three AMF exposures.