10.1021/nn100870z.s001 Raja Shekar Rachakatla Raja Shekar Rachakatla Sivasai Balivada Sivasai Balivada Gwi-Moon Seo Gwi-Moon Seo Carl B. Myers Carl B. Myers Hongwang Wang Hongwang Wang Thilani N. Samarakoon Thilani N. Samarakoon Raj Dani Raj Dani Marla Pyle Marla Pyle Franklin O. Kroh Franklin O. Kroh Brandon Walker Brandon Walker Xiaoxuan Leaym Xiaoxuan Leaym Olga B. Koper Olga B. Koper Viktor Chikan Viktor Chikan Stefan H. Bossmann Stefan H. Bossmann Masaaki Tamura Masaaki Tamura Deryl L. Troyer Deryl L. Troyer Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells American Chemical Society 2010 cell delivery vehicles AMF MNP melanoma progenitor cells NPC tumor Neural Progenitor CellsLocalized 2010-12-28 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Attenuation_of_Mouse_Melanoma_by_A_C_Magnetic_Field_after_Delivery_of_Bi_Magnetic_Nanoparticles_by_Neural_Progenitor_Cells/2702131 Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane−porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe<sub>3</sub>O<sub>4</sub> MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (<i>p</i> < 0.05) a short time (24 h) after the last of three AMF exposures.