%0 Journal Article %A Huang, Zhangjian %A Knaus, Edward E. %D 2011 %T O2-(N-Hydroxy(methoxy)-2-ethanesulfonamido) Protected Diazen-1-ium-1,2-diolates: Nitric Oxide Release via a Base-Induced β-Elimination Cleavage %U https://acs.figshare.com/articles/journal_contribution/_i_O_i_sup_2_sup_i_N_i_Hydroxy_methoxy_2_ethanesulfonamido_Protected_Diazen_1_ium_1_2_diolates_Nitric_Oxide_Release_via_a_Base_Induced_Elimination_Cleavage/2687128 %R 10.1021/ol200053z.s001 %2 https://acs.figshare.com/ndownloader/files/4356322 %K presence %K novel type %K elimination %K base DBU %K pH %K PBS %K CleavageO %K Elimination %K acids Arg %K Nitric oxide release studies %K thioacetate oxidation reaction %K cleavage %K Oxide %K Protected %K Diazen %K Release %K nonphysiological %K diazeniumdiolate %K diazen %X O2-(Ethanesulfohydroxamic acid) and O2-(N-methoxy-2-ethanesulfonylamido) diazen-1-ium-1,2-diolates (47), a novel type of O2-(protected) diazeniumdiolate, were synthesized using a key thioacetate oxidation reaction. Nitric oxide release studies showed that O2-(N-methoxy-2-ethanesulfonylamido) diazeniumdiolates 5 and 7 released NO in a nonphysiological alkaline buffer, in the presence of bases such as the basic natural amino acids Arg and His, or the non-nucleophilic organic base DBU in PBS at pH 7.4, via a β-elimination cleavage reaction. %I ACS Publications