%0 Journal Article
%A Huang, Zhangjian
%A Knaus, Edward E.
%D 2011
%T O2-(N-Hydroxy(methoxy)-2-ethanesulfonamido) Protected Diazen-1-ium-1,2-diolates: Nitric Oxide Release via a Base-Induced β-Elimination Cleavage
%U https://acs.figshare.com/articles/journal_contribution/_i_O_i_sup_2_sup_i_N_i_Hydroxy_methoxy_2_ethanesulfonamido_Protected_Diazen_1_ium_1_2_diolates_Nitric_Oxide_Release_via_a_Base_Induced_Elimination_Cleavage/2687128
%R 10.1021/ol200053z.s001
%2 https://acs.figshare.com/ndownloader/files/4356322
%K presence
%K novel type
%K elimination
%K base DBU
%K pH
%K PBS
%K CleavageO
%K Elimination
%K acids Arg
%K Nitric oxide release studies
%K thioacetate oxidation reaction
%K cleavage
%K Oxide
%K Protected
%K Diazen
%K Release
%K nonphysiological
%K diazeniumdiolate
%K diazen
%X O2-(Ethanesulfohydroxamic acid) and O2-(N-methoxy-2-ethanesulfonylamido) diazen-1-ium-1,2-diolates (4−7), a novel type of O2-(protected) diazeniumdiolate, were synthesized using a key thioacetate oxidation reaction. Nitric oxide release studies showed that O2-(N-methoxy-2-ethanesulfonylamido) diazeniumdiolates 5 and 7 released NO in a nonphysiological alkaline buffer, in the presence of bases such as the basic natural amino acids Arg and His, or the non-nucleophilic organic base DBU in PBS at pH 7.4, via a β-elimination cleavage reaction.
%I ACS Publications