Lehualides E−K, Cytotoxic Metabolites from the Tongan Marine Sponge <i>Plakortis</i> sp.
Jacqueline M. Barber
Natelle C. H. Quek
Dora C. Leahy
John H. Miller
David S. Bellows
Peter T. Northcote
10.1021/np100868t.s001
https://acs.figshare.com/articles/journal_contribution/Lehualides_E_K_Cytotoxic_Metabolites_from_the_Tongan_Marine_Sponge_i_Plakortis_i_sp_/2660152
Spectroscopy-guided chemical analysis of a marine sponge from the genus <i>Plakortis</i>, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E−K (<b>5</b>−<b>11</b>), four of which incorporate various sulfur functionalities. The structures of compounds <b>5</b>−<b>11</b> were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds <b>6</b>−<b>9</b> were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild-type and a drug-sensitive mutant.
2011-04-25 00:00:00
spectroscopic data
sulfur functionalities
genus Plakortis
polyketide origin
HL
yeast strains
model compounds
marine sponge