Lehualides E−K, Cytotoxic Metabolites from the Tongan Marine Sponge <i>Plakortis</i> sp. Jacqueline M. Barber Natelle C. H. Quek Dora C. Leahy John H. Miller David S. Bellows Peter T. Northcote 10.1021/np100868t.s001 https://acs.figshare.com/articles/journal_contribution/Lehualides_E_K_Cytotoxic_Metabolites_from_the_Tongan_Marine_Sponge_i_Plakortis_i_sp_/2660152 Spectroscopy-guided chemical analysis of a marine sponge from the genus <i>Plakortis</i>, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E−K (<b>5</b>−<b>11</b>), four of which incorporate various sulfur functionalities. The structures of compounds <b>5</b>−<b>11</b> were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds <b>6</b>−<b>9</b> were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild-type and a drug-sensitive mutant. 2011-04-25 00:00:00 spectroscopic data sulfur functionalities genus Plakortis polyketide origin HL yeast strains model compounds marine sponge