%0 Generic %A Tabata, Hidetsugu %A Wada, Naoya %A Takada, Yuko %A Oshitari, Tetsuta %A Takahashi, Hideyo %A Natsugari, Hideaki %D 2011 %T Isolation and Characterization of Atropisomers of Seven-Membered-Ring Benzolactams %U https://acs.figshare.com/articles/dataset/Isolation_and_Characterization_of_Atropisomers_of_Seven_Membered_Ring_Benzolactams/2640985 %R 10.1021/jo2008725.s005 %2 https://acs.figshare.com/ndownloader/files/4293040 %K benzolactam %K atropisomer %K benzothiazepin %K BenzolactamsThe %K moiety %K barrier %K atropisomeric %K crystallography %K benzodiazepin %K Isolation %K diastereomer %K benzazepin %K Characterization %K interconversion %K Atropisomer %X The atropisomeric properties of seven-membered-ring benzolactams (7ac and 8a) [1,5-benzodiazepin-2-one (a), 1,5-benzothiazepin-4-one (b), and 1-benzazepin-2-one (c)] were examined. The atropisomers were isolated as the diastereomers with an (S)-phenethylamide moiety, which were characterized by X-ray crystallography, and the barriers to their interconversion were clarified. %I ACS Publications