10.1021/np200056e.s001 Tzong-Huei Lee Tzong-Huei Lee Chung-Kuang Lu Chung-Kuang Lu Guei-Jane Wang Guei-Jane Wang Ya-Chih Chang Ya-Chih Chang Wen-Bin Yang Wen-Bin Yang Yu-Min Ju Yu-Min Ju Sesquiterpene Glycosides from <i>Cosmospora joca</i> American Chemical Society 2011 100 μ M nitric oxide sesquiterpene moiety Sesquiterpene Glycosides Cosmospora joca RAW spectroscopic data analyses monosaccharide composition analyses LPS ethyl acetate Cosmospora jocaFive novel sesquiterpene glycosides monosaccharide chirality analyses configuration NOESY assignments concentration value 2011-07-22 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Sesquiterpene_Glycosides_from_i_Cosmospora_joca_i_/2629074 Five novel sesquiterpene glycosides, namely, cosmosporasides A–E (<b>1</b>–<b>5</b>), were isolated from the ethyl acetate extract of the fermented broth of <i>Cosmospora joca</i>. The structures of <b>1</b>–<b>5</b> were elucidated on the basis of spectroscopic data analyses, monosaccharide composition analyses, and monosaccharide chirality analyses. The relative configuration of the sesquiterpene moiety of <b>3</b>–<b>5</b> was determined by <i>J</i>-based configuration analyses and supported by NOESY assignments. The inhibitory effects of <b>1</b>–<b>5</b> on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were evaluated; all except <b>3</b> inhibited NO production at 100 μM. <b>4</b> was the most potent, with an average maximum inhibition and a median inhibitory concentration value of 71.70 ± 1.23% and 65.98 ± 0.53 μM, respectively.