10.1021/es104295m.s001
Rosemary Castorina
Rosemary
Castorina
Asa Bradman
Asa
Bradman
Andreas Sjödin
Andreas
Sjödin
Laura Fenster
Laura
Fenster
Richard S. Jones
Richard S.
Jones
Kim G. Harley
Kim G.
Harley
Ellen A. Eisen
Ellen A.
Eisen
Brenda Eskenazi
Brenda
Eskenazi
Determinants of Serum Polybrominated Diphenyl Ether (PBDE) Levels among Pregnant Women in the CHAMACOS Cohort
American Chemical Society
2011
BMI
CHAMACOS
multivariable regression models
Serum Polybrominated Diphenyl Ether
SES
congener
PBDE levels
10 polybrominated diphenyl ether
CI
CA
U.S
2011-08-01 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Determinants_of_Serum_Polybrominated_Diphenyl_Ether_PBDE_Levels_among_Pregnant_Women_in_the_CHAMACOS_Cohort/2627274
We measured levels of 10 polybrominated diphenyl ether (PBDE) congeners in serum collected during pregnancy and at delivery from 416 pregnant, predominantly immigrant, women living in Monterey County, CA. The most frequently detected congeners were BDE-47, -99, -100, and -153, all components of the penta mixture, detected in >97% of samples. We used multivariable regression models to examine factors associated with exposure to individual PBDE congeners as well as their total summed concentration (ng/g lipid). Prenatal and delivery total PBDE levels were correlated between sampling times (<i>n</i> = 21; Pearson <i>r</i> = 0.99, <i>p</i> < 0.001). In multivariable models, total PBDE levels increased significantly with time residing in the U.S. (<i>p</i> < 0.001) and among women with ≥3 pieces of stuffed furniture in their homes (<i>p</i> < 0.05). Women’s total PBDE levels increased 4.0% (95% CI = 2.8, 5.3) for each additional year residing in the U.S., after adjustment for prepregnancy BMI, weight gain during pregnancy, and SES. Having ≥3 pieces of stuffed furniture in the home was associated with a 26.8% (95% CI = 2.0, 57.5) increase in women’s serum PBDE levels. Findings suggest PBDE indoor contamination in California homes is contributing to human exposures in a population of recent immigrants.