Platinum-Catalyzed Diastereoselective Intramolecular Coupling of Allyl Halides and Hydrazones Jong-Tai Hong Hye-Young Jang 10.1021/jo200993v.s001 https://acs.figshare.com/articles/journal_contribution/Platinum_Catalyzed_Diastereoselective_Intramolecular_Coupling_of_Allyl_Halides_and_Hydrazones/2621986 Nucleophilic allyl platinum addition to hydrazones under platinum-catalyzed conditions was studied. To generate nucleophilic allyl platinum complexes, allyl halides were employed with platinum complexes, SnCl<sub>2</sub>, and H<sub>2</sub>. The allyl platinum(IV) intermediates reacted with the hydrazone to give the corresponding cyclic amine derivatives in good yield and with excellent diastereoselectivity. The cis selectivity of N-tethered substrates was attributed to a tight interaction of allyl platinum species with the hydrazone, on the basis of the results of solvent screening and acid/base addition experiments. 2011-08-19 00:00:00 hydrazone allyl halides cyclic amine derivatives cis selectivity H 2. Allyl Halides nucleophilic allyl platinum complexes allyl platinum species platinum complexes HydrazonesNucleophilic allyl platinum addition