Iwai, Tomohiro Fujihara, Tetsuaki Terao, Jun Tsuji, Yasushi Iridium-Catalyzed Addition of Aroyl Chlorides and Aliphatic Acid Chlorides to Terminal Alkynes Iridium complexes show high catalytic activity in intermolecular additions of acid chlorides to terminal alkynes to afford valuable (<i>Z</i>)-β-chloro-α,β-unsaturated ketones. Ligands in the catalytic system play a crucial role in this reaction. An <i>N</i>-heterocyclic carbene (NHC) is an efficient ligand for the addition of aroyl chlorides, while dicyclohexyl­(2-methylphenyl)­phosphine (PCy<sub>2</sub>(<i>o</i>-Tol)) is indispensable for the reaction of aliphatic acid chlorides. The addition reactions proceed regio- and stereoselectively with suppression of decarbonylation and β-hydrogen elimination, which have been two major intrinsic problems in transition-metal-catalyzed reactions. Stoichiometric reactions of active iridium catalysts with aroyl chlorides and aliphatic acid chlorides are carried out to gain insights into the reaction mechanisms. NHC;aroyl chlorides;Terminal AlkynesIridium complexes show;aliphatic acid chlorides 2012-01-18
    https://acs.figshare.com/articles/dataset/Iridium_Catalyzed_Addition_of_Aroyl_Chlorides_and_Aliphatic_Acid_Chlorides_to_Terminal_Alkynes/2564485
10.1021/ja209679c.s002