Antiviral Properties of
Polymeric Aziridine- and Biguanide-Modified
Core–Shell Magnetic Nanoparticles
Lev Bromberg
Daniel
J. Bromberg
T. Alan Hatton
Isabel Bandín
Angel Concheiro
Carmen Alvarez-Lorenzo
10.1021/la205127x.s001
https://acs.figshare.com/articles/journal_contribution/Antiviral_Properties_of_Polymeric_Aziridine_and_Biguanide_Modified_Core_Shell_Magnetic_Nanoparticles/2544244
Polycationic superparamagnetic nanoparticles (∼150–250
nm) were evaluated as virucidal agents. The particles possess a core–shell
structure, with cores consisting of magnetite clusters and shells
of functional silica covalently bound to poly(hexamethylene biguanide)
(PHMBG), polyethyleneimine (PEI), or PEI terminated with aziridine
moieties. Aziridine was conjugated to the PEI shell through cationic
ring-opening polymerization. The nanometric core–shell particles
functionalized with biguanide or aziridine moieties are able to bind
and inactivate bacteriophage MS2, herpes simplex virus HSV-1, nonenveloped
infectious pancreatic necrosis virus (IPNV), and enveloped viral hemorrhagic
septicaemia virus (VHSV). The virus–particle complexes can
be efficiently removed from the aqueous milieu by simple magnetocollection.
2012-03-06 00:00:00
PHMBG
aziridine moieties
pancreatic necrosis virus
HSV
VHSV
core
MS
hemorrhagic septicaemia virus
Aziridine
IPNV
biguanide
PEI