10.1021/la205127x.s001 Lev Bromberg Lev Bromberg Daniel J. Bromberg Daniel J. Bromberg T. Alan Hatton T. Alan Hatton Isabel Bandín Isabel Bandín Angel Concheiro Angel Concheiro Carmen Alvarez-Lorenzo Carmen Alvarez-Lorenzo Antiviral Properties of Polymeric Aziridine- and Biguanide-Modified Core–Shell Magnetic Nanoparticles American Chemical Society 2012 PHMBG aziridine moieties pancreatic necrosis virus HSV VHSV core MS hemorrhagic septicaemia virus Aziridine IPNV biguanide PEI 2012-03-06 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Antiviral_Properties_of_Polymeric_Aziridine_and_Biguanide_Modified_Core_Shell_Magnetic_Nanoparticles/2544244 Polycationic superparamagnetic nanoparticles (∼150–250 nm) were evaluated as virucidal agents. The particles possess a core–shell structure, with cores consisting of magnetite clusters and shells of functional silica covalently bound to poly­(hexamethylene biguanide) (PHMBG), polyethyleneimine (PEI), or PEI terminated with aziridine moieties. Aziridine was conjugated to the PEI shell through cationic ring-opening polymerization. The nanometric core–shell particles functionalized with biguanide or aziridine moieties are able to bind and inactivate bacteriophage MS2, herpes simplex virus HSV-1, nonenveloped infectious pancreatic necrosis virus (IPNV), and enveloped viral hemorrhagic septicaemia virus (VHSV). The virus–particle complexes can be efficiently removed from the aqueous milieu by simple magnetocollection.