10.1021/la300612k.s001
Yibo Xing
Yibo
Xing
Chao Wang
Chao
Wang
Peng Han
Peng
Han
Zhiqiang Wang
Zhiqiang
Wang
Xi Zhang
Xi
Zhang
Acetylcholinesterase Responsive
Polymeric Supra-Amphiphiles
for Controlled Self-Assembly and Disassembly
American Chemical Society
2012
enzyme
Nile
aggregate
acetylcholinesterase
myristoylcholine chloride
2012-04-10 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Acetylcholinesterase_Responsive_Polymeric_Supra_Amphiphiles_for_Controlled_Self_Assembly_and_Disassembly/2532640
We have fabricated enzyme responsive polymeric supra-amphiphiles
by mixing a block copolymer of poly(ethylene glycol)-<i>block</i>-poly(acrylic acid) with myristoylcholine chloride in water. The
polymeric supra-amphiphiles self-assemble into spherical aggregates
with sizes varying from about 40 to 150 nm. Moreover, the spherical
aggregates can be disassembled triggered by acetylcholinesterase,
an enzyme which can cut off the ester linkage of myristoylcholine
chloride. Nile red can be loaded into the spherical aggregates and
released in several hours upon the treatment of acetylcholinesterase.
The releasing rate is rather fast considering that it takes more than
150 h for Nile red to diffuse out of the spherical aggregates without
addition of acetylcholinesterase. It is anticipated that the new enzyme
responsive polymeric supra-amphiphile may be explored as a carrier
for drug delivery.