10.1021/jo300063u.s001 Chun-Fang Wu Chun-Fang Wu Xin Zhao Xin Zhao Wen-Xian Lan Wen-Xian Lan Chunyang Cao Chunyang Cao Jin-Tao Liu Jin-Tao Liu Xi-Kui Jiang Xi-Kui Jiang Zhan-Ting Li Zhan-Ting Li A 1,4-Diphenyl-1,2,3-Triazole-Based β-Turn Mimic Constructed by Click Chemistry American Chemical Society 2012 ether O atoms motif skeleton compound hairpin Diphenyl intramolecular candidate diphenyl derivative Mimic Constructed conformation H atom formation 1 H NMR studies 2 D amide triazole C Click ChemistryA series Such 2012-05-04 00:00:00 Dataset https://acs.figshare.com/articles/dataset/A_1_4_Diphenyl_1_2_3_Triazole_Based_Turn_Mimic_Constructed_by_Click_Chemistry/2525230 A series of 1,4-diphenyl-1,2,3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic and (1D and 2D) <sup>1</sup>H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C–H···O hydrogen-bonding formed between the triazole C-5 H atom and the two ether O atoms. Such folded structures make this 1,4-diphenyl-1,2,3-triazole skeleton a good candidate to be used as β-turn mimic. To prove this, the formation of a β-hairpin structure induced by this β-turn motif has been further demonstrated.