10.1021/jo300063u.s001
Chun-Fang Wu
Chun-Fang
Wu
Xin Zhao
Xin
Zhao
Wen-Xian Lan
Wen-Xian
Lan
Chunyang Cao
Chunyang
Cao
Jin-Tao Liu
Jin-Tao
Liu
Xi-Kui Jiang
Xi-Kui
Jiang
Zhan-Ting Li
Zhan-Ting
Li
A 1,4-Diphenyl-1,2,3-Triazole-Based
β-Turn Mimic
Constructed by Click Chemistry
American Chemical Society
2012
ether O atoms
motif
skeleton
compound
hairpin
Diphenyl
intramolecular
candidate
diphenyl
derivative
Mimic Constructed
conformation
H atom
formation
1 H NMR studies
2 D
amide
triazole C
Click ChemistryA series
Such
2012-05-04 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/A_1_4_Diphenyl_1_2_3_Triazole_Based_Turn_Mimic_Constructed_by_Click_Chemistry/2525230
A series of 1,4-diphenyl-1,2,3-triazole-incorporated
amide derivatives
have been designed and prepared. X-ray crystallographic and (1D and
2D) <sup>1</sup>H NMR studies reveal that these compounds fold into
stable U-shaped conformations driven by three-center intramolecular
C–H···O hydrogen-bonding formed between the
triazole C-5 H atom and the two ether O atoms. Such folded structures
make this 1,4-diphenyl-1,2,3-triazole skeleton a good candidate to
be used as β-turn mimic. To prove this, the formation of a β-hairpin
structure induced by this β-turn motif has been further demonstrated.