Lipase Is Essential for
the Study of <i>in Vitro</i> Release Kinetics from Organogels
Marie-Hélène Dufresne
Elaheh Marouf
Yvonne Kränzlin
Marc A. Gauthier
Jean-Christophe Leroux
10.1021/mp3001099.s001
https://acs.figshare.com/articles/journal_contribution/Lipase_Is_Essential_for_the_Study_of_i_in_Vitro_i_Release_Kinetics_from_Organogels/2517499
<i>In vitro</i> drug release studies remain
indispensable
in the development of drug delivery systems, even if correlations
between <i>in vitro</i> and <i>in vivo</i> results
are often imperfect. In this work, an improved <i>in vitro</i> analysis method for studying <i>in situ</i>-forming lipid-based
implants was developed. More specifically, lipase was found to be
an essential additive for evidencing differences in drug release kinetics
from organogels of different amino acid-based organogelators,
organogelator concentrations, drug loadings, and volumes. Lipases
are thought to participate in the degradation of and release from
amino acid-based organogel implants <i>in vivo</i>. Our
experimental conditions allowed for the rapid and reliable screening
of <i>in vitro</i> parameters that may be optimized to slow
or accelerate drug release, once preliminary <i>in vivo</i> data are available.
2016-02-20 20:30:22
drug release studies
drug release kinetics
drug loadings
implant
Lipase
drug release
vivo data
drug delivery systems
organogelator concentrations
Vitro Release Kinetics
analysis method
vivo results