A Facile Method to Synthesize Histones with Posttranslational Modification Mimics WangZhiyong U. WangYane-Shih PaiPei-Jing RussellWilliam K. RussellDavid H. LiuWenshe R. 2012 Using an evolved pyrrolysyl-tRNA synthetase-tRNA<sup>Pyl</sup> pair, a <i>Se</i>-alkylselenocysteine was genetically incorporated into histone H3 with a high protein expression yield. Quantitative oxidative elimination of <i>Se</i>-alkylselenocysteine followed by Michael addition reactions with various thiol nucleophiles generated biologically active mimics of H3 with posttranslational modifications including lysine methylation, lysine acetylation, and serine phosphorylation.