%0 Journal Article %A Mita, Tsuyoshi %A Michigami, Kenichi %A Sato, Yoshihiro %D 2012 %T Sequential Protocol for C(sp3)–H Carboxylation with CO2: Transition-Metal-Catalyzed Benzylic C–H Silylation and Fluoride-Mediated Carboxylation %U https://acs.figshare.com/articles/journal_contribution/Sequential_Protocol_for_C_sp_sup_3_sup_H_Carboxylation_with_CO_sub_2_sub_Transition_Metal_Catalyzed_Benzylic_C_H_Silylation_and_Fluoride_Mediated_Carboxylation/2507551 %R 10.1021/ol301431d.s001 %2 https://acs.figshare.com/ndownloader/files/4150480 %K C 1 source %K Sequential Protocol %K CO 2 gas %K CO 2 %K carboxylation %K sequential protocol %K bond %X One of the most challenging transformations in current organic chemistry is the catalytic carboxylation of a C(sp3)–H bond using CO2 gas, an inexpensive and ubiquitous C1 source. A sequential protocol for C(sp3)–H carboxylation by employing a nitrogen-directed, metal-assisted, C–H activation/catalytic silylation reaction in conjunction with fluoride-mediated carboxylation with CO2 was established. The carboxylation proceeded only at the benzylic C(sp3)–Si bond, not at the aromatic C(sp2)–Si, which is advantageous for further manipulations of the products. %I ACS Publications