%0 Journal Article
%A Mita, Tsuyoshi
%A Michigami, Kenichi
%A Sato, Yoshihiro
%D 2012
%T Sequential Protocol for C(sp3)–H Carboxylation with CO2: Transition-Metal-Catalyzed Benzylic C–H Silylation and Fluoride-Mediated Carboxylation
%U https://acs.figshare.com/articles/journal_contribution/Sequential_Protocol_for_C_sp_sup_3_sup_H_Carboxylation_with_CO_sub_2_sub_Transition_Metal_Catalyzed_Benzylic_C_H_Silylation_and_Fluoride_Mediated_Carboxylation/2507551
%R 10.1021/ol301431d.s001
%2 https://acs.figshare.com/ndownloader/files/4150480
%K C 1 source
%K Sequential Protocol
%K CO 2 gas
%K CO 2
%K carboxylation
%K sequential protocol
%K bond
%X One of the most challenging transformations in current organic chemistry is the catalytic carboxylation of a C(sp3)–H bond using CO2 gas, an inexpensive and ubiquitous C1 source. A sequential protocol for C(sp3)–H carboxylation by employing a nitrogen-directed, metal-assisted, C–H activation/catalytic silylation reaction in conjunction with fluoride-mediated carboxylation with CO2 was established. The carboxylation proceeded only at the benzylic C(sp3)–Si bond, not at the aromatic C(sp2)–Si, which is advantageous for further manipulations of the products.
%I ACS Publications