10.1021/ol301513h.s002
Naim Nazef
Naim
Nazef
Robert D. M. Davies
Robert
D. M. Davies
Michael F. Greaney
Michael F.
Greaney
Formal Synthesis of Merrilactone A Using a Domino Cyanide 1,4-Addition–Aldol Cyclization
American Chemical Society
2012
domino
stereocenter
Merrilactone
CyclizationA
Formal Synthesis
cyclization
merrilactone
cyano
synthesis
Cyanide
latter method
iodo
Domino
bond
2012-07-20 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Formal_Synthesis_of_Merrilactone_A_Using_a_Domino_Cyanide_1_4_Addition_Aldol_Cyclization/2503624
A formal synthesis of merrilactone A has been completed using a domino 1,4-addition–aldol process as the key step. Both iodo- and cyano-1,4-addition–aldol cyclizations were productive in forming the highly hindered C1–C9 bond linking <i>vic</i>-quaternary and tertiary stereocenters. The latter method was used to complete a formal total synthesis of the natural product.