10.1021/ol301513h.s002 Naim Nazef Naim Nazef Robert D. M. Davies Robert D. M. Davies Michael F. Greaney Michael F. Greaney Formal Synthesis of Merrilactone A Using a Domino Cyanide 1,4-Addition–Aldol Cyclization American Chemical Society 2012 domino stereocenter Merrilactone CyclizationA Formal Synthesis cyclization merrilactone cyano synthesis Cyanide latter method iodo Domino bond 2012-07-20 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Formal_Synthesis_of_Merrilactone_A_Using_a_Domino_Cyanide_1_4_Addition_Aldol_Cyclization/2503624 A formal synthesis of merrilactone A has been completed using a domino 1,4-addition–aldol process as the key step. Both iodo- and cyano-1,4-addition–aldol cyclizations were productive in forming the highly hindered C1–C9 bond linking <i>vic</i>-quaternary and tertiary stereocenters. The latter method was used to complete a formal total synthesis of the natural product.