Ohlendorf, Birgit Schulz, Dirk Erhard, Arlette Nagel, Kerstin Imhoff, Johannes F. Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a <i>Streptomyces</i> Species Geranylphenazinediol (<b>1</b>), a new phenazine natural product, was produced by the <i>Streptomyces</i> sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. <b>1</b> inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of <b>1</b>, its inhibitory potential was compared to that of related structures. activity profile;Geranylphenazinediol;strain;Streptomyces sp;micromolar range;LB;marine sediment sample;Acetylcholinesterase Inhibitor Produced;SpeciesGeranylphenazinediol;phenazine;enzyme acetylcholinesterase;NMR;analysis;MS data 2012-07-27
    https://acs.figshare.com/articles/journal_contribution/Geranylphenazinediol_an_Acetylcholinesterase_Inhibitor_Produced_by_a_i_Streptomyces_i_Species/2501410
10.1021/np2009626.s001