Geranylphenazinediol,
an Acetylcholinesterase Inhibitor
Produced by a <i>Streptomyces</i> Species
Birgit Ohlendorf
Dirk Schulz
Arlette Erhard
Kerstin Nagel
Johannes F. Imhoff
10.1021/np2009626.s001
https://acs.figshare.com/articles/journal_contribution/Geranylphenazinediol_an_Acetylcholinesterase_Inhibitor_Produced_by_a_i_Streptomyces_i_Species/2501410
Geranylphenazinediol (<b>1</b>), a new phenazine
natural
product, was produced by the <i>Streptomyces</i> sp. strain
LB173, which was isolated from a marine sediment sample. The structure
was established by analysis of NMR and MS data. <b>1</b> inhibited
the enzyme acetylcholinesterase in the low micromolar range and showed
weak antibacterial activity. In order to get a more detailed picture
of the activity profile of <b>1</b>, its inhibitory potential
was compared to that of related structures.
2012-07-27 00:00:00
activity profile
Geranylphenazinediol
strain
Streptomyces sp
micromolar range
LB
marine sediment sample
Acetylcholinesterase Inhibitor Produced
SpeciesGeranylphenazinediol
phenazine
enzyme acetylcholinesterase
NMR
analysis
MS data