%0 Journal Article %A Nishiumi, Masami %A Miura, Hiroki %A Wada, Kenji %A Hosokawa, Saburo %A Inoue, Masashi %D 2012 %T Active Ruthenium Catalysts Based on Phosphine-Modified Ru/CeO2 for the Selective Addition of Carboxylic Acids to Terminal Alkynes %U https://acs.figshare.com/articles/journal_contribution/Active_Ruthenium_Catalysts_Based_on_Phosphine_Modified_Ru_CeO_sub_2_sub_for_the_Selective_Addition_of_Carboxylic_Acids_to_Terminal_Alkynes/2499298 %R 10.1021/cs300151x.s001 %2 https://acs.figshare.com/ndownloader/files/4142173 %K presence %K ruthenium species %K adduct %K Terminal AlkynesThe modification %K catalyst %K ceria %K Active Ruthenium Catalysts %X The modification of ruthenium species supported on ceria in the presence of suitable phosphines under H2 at 100 °C was found to generate catalytically active Ru species that were effective for the regio- and stereoselective addition of carboxylic acids to terminal alkynes. The reactions in the presence of a catalytic amount of Ru/CeO2 modified with 1,4-bis­(diphenylphosphino)­butane gave the anti-Markovnikov adducts in high yields with excellent (Z)-isomer selectivities. On the other hand, the reactions with the trioctylphosphine-modified catalyst gave the Markovnikov adducts as major products. Among the catalysts examined, only ceria- or zirconia-supported catalysts were effective, and hot filtration tests using the phosphine-modified Ru/CeO2 catalyst suggested that soluble ruthenium species showed quite a high catalytic activity. Very small amounts of ruthenium species were detected in the solution. The solid Ru/CeO2 could be repeatedly used as a reservoir of active catalysts without a significant loss of activity. %I ACS Publications