10.1021/ac301523n.s001
Lin-Ai Tai
Lin-Ai
Tai
Yu-Ting Kang
Yu-Ting
Kang
Yu-Ching Chen
Yu-Ching
Chen
Yu-Chao Wang
Yu-Chao
Wang
Yu-Jing Wang
Yu-Jing
Wang
Yu-Ting Wu
Yu-Ting
Wu
Kuo-Liang Liu
Kuo-Liang
Liu
Chiu-Yen Wang
Chiu-Yen
Wang
Yu-Feng Ko
Yu-Feng
Ko
Ching-Ya Chen
Ching-Ya
Chen
Nai-Chun Huang
Nai-Chun
Huang
Jen-Kun Chen
Jen-Kun
Chen
Yong-Fen Hsieh
Yong-Fen
Hsieh
Tri-Rung Yew
Tri-Rung
Yew
Chung-Shi Yang
Chung-Shi
Yang
Quantitative Characterization
of Nanoparticles in Blood by Transmission Electron Microscopy with
a Window-Type Microchip Nanopipet
American Chemical Society
2012
Quantitative Characterization
solution
nanoparticle
chamber width
TEM holders
sampling device
Transmission Electron Microscopy
microchip nanopipet
particle concentration
copper grids
aggregation
2012-08-07 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Quantitative_Characterization_of_Nanoparticles_in_Blood_by_Transmission_Electron_Microscopy_with_a_Window_Type_Microchip_Nanopipet/2498503
Transmission electron microscopy (TEM) is a unique and
powerful tool for observation of nanoparticles. However, due to the
uneven spatial distribution of particles conventionally dried on copper
grids, TEM is rarely employed to evaluate the spatial distribution
of nanoparticles in aqueous solutions. Here, we present a microchip
nanopipet with a narrow chamber width for sorting nanoparticles from
blood and preventing the aggregation of the particles during the drying
process, enabling quantitative analysis of their aggregation/agglomeration
states and the particle concentration in aqueous solutions. This microchip
is adaptable to all commercial TEM holders. Such a nanopipet proves
to be a simple and convenient sampling device for TEM image-based
quantitative characterization.