Kuo, Louis Y. Bentley, Anne K. Shari’ati, Yusef A. Smith, Curtis P. Phosphonothioate Hydrolysis Turnover by Cp<sub>2</sub>MoCl<sub>2</sub> and Silver Nanoparticles The metallocene bis­(cyclopentadienyl)­molybdenum­(IV) dichloride (Cp<sub>2</sub>MoCl<sub>2</sub>; Cp = η<sup>5</sup>-C<sub>5</sub>H<sub>5</sub>) is the first organometallic compound to promote the hydrolysis of phosphonothioates with selective P–S scission in a stoichiometric fashion. This report shows that silver nanoparticles capped with borohydride ions promote turnover in this hydrolytic process, as indicated by <sup>31</sup>P NMR studies on the reaction of <i>O</i>,<i>S</i>-diethyl phenylphosphonothioate (DEPP) with Cp<sub>2</sub>MoCl<sub>2</sub> (pH 7). This is the first example of the joint use of nanoparticles and molybdenum metallocenes to promote phosphonothioate hydrolysis. Initial results indicate the turnover may be due to free Ag<sup>+</sup>(aq) ions present in the solution that arise either from the slow dissolution of the nanoparticles or from interactions with the Ag nanoparticle surface. metallocene;Cp 2MoCl Cp;Ag nanoparticle surface;5H;phosphonothioate;Phosphonothioate Hydrolysis Turnover;DEPP;31 P NMR studies;ion;hydrolysis;Cp 2MoCl 2012-08-13
    https://acs.figshare.com/articles/journal_contribution/Phosphonothioate_Hydrolysis_Turnover_by_Cp_sub_2_sub_MoCl_sub_2_sub_and_Silver_Nanoparticles/2497108
10.1021/om300251w.s001